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KMID : 0364219890320020163
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Korean Journal of Zoology
1989 Volume.32 No. 2 p.163 ~ p.175
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Alteration in the Transferrin Receptor during the Chick Myoblast Fusion in Culture
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Lee Chang-Ho
Yoo Baeng-Jae
Jeon Young-Ju
Chung Chin-Ha
Ha Doo-Bong
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Abstract
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Transferrin (Tf) has been known to exert profound effect on the myoblast differentiation in uirto. Therefore, the changes in the amount and affinity of the Tf receptor would accompany the myoblast differentiation. To investigate this possibility, we exarnined the afteration pattern in the level of the Tf receptor during the myoblast fusion. The level of Tf receptor was assayed by measuring the bound 125 I-Tf onto the surface of cultured myoblasts, and it was known that the level of Tf receptor reached the maximum at about 12 hr before the initi ation of the myoblast fusion and decreased as the differentiation proceeded, and that the affinity of Tf receptor to Tf was also decreased. In addition, various inhibitiors of the myoblast fusion also influenced the level of the Tf receptor. Accroding to these results, it is postulated that the level of Tf receptor is highly regulated during the myoblast differentiation.
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KEYWORD
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Transferrin receptror , Chick myoblast differentiation
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